DPYD Pharmacogenomics Testing

All patients, prior to commencing treatment with fluoropyrimidine based therapy (5- fluorouracil, capecitabine or tegafur) should be screened for the following five DPYD variants; c.557A>G p.(Tyr186Cys), c.1129–5923C>G, c.1679T>G p.(Ile560Ser), c.1905+1G>A and c.2846A>T p.(Asp949Val). Further details can be found on the DPYD information sheet