Genomic Testing in Adult Solid Tumours
There are 29 Clinical Indications included in the Cancer National Genomics Test Directory for Adult Solid Tumours [1]. For each of the clinical indications listed below testing is provided by all 7 Genomic Laboratory Hubs across England. The test directory includes both targeted genetic testing and panel testing using next generation sequencing (NGS) technology. The West Midlands Regional Genetics Laboratory provides a centralised cancer panel testing service (both DNA and RNA panels) for the Central and South GLH Consortium.
WMRGL provides NGS panel testing for the clinical indications listed below:
***Please note unlinked test detail information will be added as soon as possible***
|
Test Directory Clinical Indication |
Directory Code |
DNA Panel Test |
Fusion Panel Test |
Link for test details |
|---|---|---|---|---|
|
Adenoid Cystic Carcinoma |
M16 |
|
YES |
[link to sheet M16] |
|
Adrenal Cortical Carcinoma |
M14 |
YES |
YES |
[link to sheet M14] |
|
Bladder Cancer |
M217 |
YES |
YES |
[link to sheet M207] |
|
Breast Cancer |
M3 |
|
YES |
[link to sheet M3] |
|
Cancer of Unknown Primary |
M226 |
|
YES |
[link to sheet M226] |
|
Cholangiocarcinoma |
M220 |
|
YES |
[link to sheet M220] |
|
Colorectal Carcinoma |
M1 |
YES |
YES |
[link to sheet M1] |
|
Endometrial Cancer |
M215 |
|
YES |
[link to sheet M215] |
|
Gastrointestinal Stromal Tumour |
M8 |
YES |
YES |
[link to sheet M8] |
|
Head and Neck Squamous Cell Carcinoma |
M15 |
YES |
YES |
[link to sheet M15] |
|
Hepatocellular carcinoma |
M222 |
|
YES |
[link to sheet M222] |
|
Melanoma |
M7 |
YES |
YES |
[link to sheet M7] |
|
Mesothelioma |
M5 |
YES |
YES |
[link to sheet M5] |
|
Mucoepidermoid Carcinoma |
M6 |
|
YES |
[link to sheet M6] |
|
Non-Small Cell Lung Cancer |
M4 |
YES |
YES |
[link to sheet M4] |
|
Ovarian Carcinoma |
M2 |
YES |
YES |
[link to sheet M2] |
|
Pancreatic Cancer |
M219 |
YES |
YES |
[link to sheet M219] |
|
Phaeochromocytoma |
M13 |
YES |
YES |
[link to sheet M13] |
|
Poorly Differentiated Anaplastic Thyroid Carcinoma |
M11 |
YES |
YES |
[link to sheet M11] |
|
Prostate Cancer |
M218 |
YES |
YES |
[link to sheet M218] |
|
Renal Cell Carcinoma |
M18 |
YES |
YES |
[link to sheet M18] |
|
Secretory Carcinoma (Salivary Gland) |
M17 |
|
YES |
[link to sheet M17] |
|
Small cell lung cancer |
M231 |
YES |
YES |
[link to sheet M231] |
|
Spitzoid tumour |
M221 |
|
YES |
[link to sheet M221] |
|
Thyroid Follicular Carcinoma |
M10 |
YES |
YES |
[link to sheet M10] |
|
Thyroid Medullary Carcinoma |
M12 |
YES |
YES |
[link to sheet M12] |
|
Thyroid Papillary Carcinoma |
M9 |
YES |
YES |
[link to sheet M9] |
|
Uveal melanoma |
M187 |
YES |
YES |
[link to sheet M187] |
|
NTRK testing – all above solid cancers |
All codes |
|
YES |
|
|
DPYD testing – all eligible solid cancers |
All codes |
|
|
Patients who are eligible for an NGS panel test should be referred to the WMRGL for genetic testing.
Please contact Dr Yvonne Wallis (y.wallis@nhs.net) if sending requests for the first time to discuss your requirements in more detail.
Please use the WMRGL Cancer Genomic Test Request Form