Genomic Testing in Adult Solid Tumours

There are 29 Clinical Indications included in the Cancer National Genomics Test Directory for Adult Solid Tumours [1].  For each of the clinical indications listed below testing is provided by all 7 Genomic Laboratory Hubs across England. The test directory includes both targeted genetic testing and panel testing using next generation sequencing (NGS) technology. The West Midlands Regional Genetics Laboratory provides a centralised cancer panel testing service (both DNA and RNA panels) for the Central and South GLH Consortium.

WMRGL provides NGS panel testing for the clinical indications listed below:

***Please note unlinked test detail information will be added as soon as possible***

Clinical indications

Test Directory Clinical Indication

Directory Code

DNA

Panel Test

Fusion Panel Test

Link for test details

Adenoid Cystic Carcinoma

M16

 

YES

[link to sheet M16]

Adrenal Cortical Carcinoma

M14

YES

YES

[link to sheet M14]

Bladder Cancer

M217

YES

YES

[link to sheet M207]

Breast Cancer

M3

 

YES

[link to sheet M3]

Cancer of Unknown Primary

M226

 

YES

[link to sheet M226]

Cholangiocarcinoma

M220

 

YES

[link to sheet M220]

Colorectal Carcinoma

M1

YES

YES

[link to sheet M1]

Endometrial Cancer

M215

 

YES

[link to sheet M215]

Gastrointestinal Stromal Tumour

M8

YES

YES

[link to sheet M8]

Head and Neck Squamous Cell Carcinoma

M15

YES

YES

[link to sheet M15]

Hepatocellular carcinoma

M222

 

YES

[link to sheet M222]

Melanoma

M7

YES

YES

[link to sheet M7]

Mesothelioma

M5

YES

YES

[link to sheet M5]

Mucoepidermoid Carcinoma

M6

 

YES

[link to sheet M6]

Non-Small Cell Lung Cancer

M4

YES

YES

[link to sheet M4]

Ovarian Carcinoma

M2

YES

YES

[link to sheet M2]

Pancreatic Cancer

M219

YES

YES

[link to sheet M219]

Phaeochromocytoma

M13

YES

YES

[link to sheet M13]

Poorly Differentiated Anaplastic Thyroid Carcinoma

M11

YES

YES

[link to sheet M11]

Prostate Cancer

M218

YES

YES

[link to sheet M218]

Renal Cell Carcinoma

M18

YES

YES

[link to sheet M18]

Secretory Carcinoma (Salivary Gland)

M17

 

YES

[link to sheet M17]

Small cell lung cancer

M231

YES

YES

[link to sheet M231]

Spitzoid tumour

M221

 

YES

[link to sheet M221]

Thyroid Follicular Carcinoma

M10

YES

YES

[link to sheet M10]

Thyroid Medullary Carcinoma

M12

YES

YES

[link to sheet M12]

Thyroid Papillary Carcinoma

M9

YES

YES

[link to sheet M9]

Uveal melanoma

M187

YES

YES

[link to sheet M187]

NTRK testing – all above solid cancers

All codes

 

YES

NTRK testing - adult solid tumours link [pdf] 535K

DPYD testing – all eligible solid cancers

All codes

 

 

DPYD information sheet [pdf] 675KB

Patients who are eligible for an NGS panel test should be referred to the WMRGL for genetic testing.

Please contact Dr Yvonne Wallis (y.wallis@nhs.net) if sending requests for the first time to discuss your requirements in more detail.

Please use the WMRGL Cancer Genomic Test Request Form [pdf] 147KB.

[1]https://www.england.nhs.uk/wp-content/uploads/2018/08/National-Genomic-Test-Directory-Cancer-November-2020-21.xlsx